We’ll do these one by one…
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Glucosamine - there is conflicting studies with regards to this, studies being peer-reviewed, double-blind, placebo base studies by credible sources (hence, not from the company making the supplement,not from an internet webpage that looks so official looking, not from Men’s Health, Womans Day, Prevention Magazine, etc etc…not from Oprah, or Grandma’s friend, etc…) Humans tend to really screw up studies and subjectively, how they are doing with regards to treatments/medications, hence the placebo use in studies… Most studies show a subjective response of Glucosamine and placebo to be equivalent… However, many people claim it works well for them ( and others I know reported zero effect), and it basically cannot hurt you unless you have pre-existing kidney problems, so go ahead and try it…
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MSM (Methyl Sulfonyl Methane) - no clinical proof that it works, plenty of clinical evidence it can be very dangerous…looking at this stuff and how the body metabolizes it, I would recommend staying away…in theory, it should be similar to DMSO (dimethylsulfoxide) in effect, and even more in theory, provide the sulfur which way down the pathway can be incorporated in compounds that will eventually become intergrated into cartilage and fluid found within it…it is a long pathway, and really really stretching the If’s…but who am I to judge it (cough, molecular biologist, medical student, PhD candidate in molecular biology), your body, your wallet, your call…
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Chondroiten Sulfate - good idea, in theory, just doesn’t hold up under clinical trials well…again, any second semester biochemistry student can tell you it just isn’t going to work…can’t really hurt you as with one save pre-existing renal problems if taken in high enough doses, but really a waste of money…your body, your wallet, your call…
I am sure grandma, or the local GNC guy, phrenologist, astrologer, and most definitely a few MD’s will jump all over this, go ahead, who cares…
If you really want to do something about your knees, see a sports physiologist, or sports medicine doctor…light stretches and low impact resistance training are often helpful…if you need pain relieve, or inflammation reduction, try an OTC like Aleve or another NSAID drug…stay wawy from narcotic pain analgesics, credible studies are showing they may actually SLOW the healing process… buy good shoes, fitted by somebody who knows how, to assure you are walking correctly, if you have to, see a podiatrist for orthodics…
And, if you really want to try a supplement, go with the Glucosamine for a few weeks or months, see how it does for you… the Chondroiten is extra money and a waste, I’d stay away from the MSM…
IMHO (well, maybe not being too humble here…)
xtn
airferret