Like any equipment, the right choice depends on the task at hand. For 3 season backpacking I think Down is by far the best choice. You just need to be careful to keep your bag dry. It’s hard to get the bag very wet if you are reasonably careful.
I took a tumble on a stream crossing and my pack went in the water with the sleeping bag strapped to the back… I had it in it’s water resistant stuff sack and the water did not penetrate the sack despite the dunking. I also had a down for 5 days of non-stop rain and it did not get wet, and I’m pretty klutzy and un-systematic.
If you get it wet, in warm weather, its not life or death and it would be very hard to get it so wet that it would lose all its insulation. If you are really worried about that, get a water resistant or water proof lining.
I used the Western Mountaineering Caribou to do the N.H. AT and loved it. In August, I never even zipped it up for a 2 week hike even when camping above 4,000 ft. Getting a full length zip allows you to use it as a blanket, or - on warm nights - have it aside to be used as a blanket if it gets really cool.
For long winter trips, you need to worry about build up of condensation and that can be a real problem for down insulation - there synthetic makes more sense to me. Also, the consequences of compromised insulation are more severe.
pedxing